Chemical Culprit, Chemical Cure? Challenging Conventional Wisdom on Mental Illness

The Takeaway

For almost 40 years, conventional wisdom has been that mental illness is caused by a chemical imbalance in the brain. “Serotonin” is a household word, along with Prozac, Zyprexa, and Zoloft.   But recently, there’s been a vigorous debate within the medical community over whether that line of thinking is accurate. This summer Marcia Angell, a physician, senior lecturer at Harvard, and former editor-in-chief of  The New England Journal of Medicine, wrote in the New York Review of Books  that the chemical-imbalance model of mental illness may be ineffective at best –  and harmful, at worst. In her article, Angell talked about medical journalist Robert Whitaker’s book “Anatomy of an Epidemic: Magic Bullets, Psychiatric Drugs, and the Astonishing Rise of Mental Illness in America.”  Whitaker researched years of drug trials and determined that pharmaceutical companies play an enormous role in deciding what causes mental illness, who qualifies as mentally ill, and how those illnesses should be treated.

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