The game’s afoot — from Baker Street to Minnesota to Kathmandu. We’ll follow the clues to decipher how Sherlock Holmes has stayed fresh for more than a century. We’ll meet “Sherlock Holmes in sneakers” — 5th grade detective “Encyclopedia Brown” — and also the creator of hit TV show “House,” whose powers (and weaknesses) are modeled on Holmes’. Plus, a conversation with rock and roll poet Patti Smith, who is the subject of a new documentary airing on PBS.