The CDC released a startling statistic recently. In the 12 months ending in April 2021, more than 100,000 people died of drug overdoses in the US — the highest annual number of fatal drug overdoses ever. The powerful synthetic opioid fentanyl is to blame for two-thirds of those deaths. Is the US an outlier where overdoses related to fentanyl are concerned? To put the US fentanyl crisis in perspective, Marco Werman speaks with Daniel Ciccarone, a professor of family medicine at the University of California, San Francisco, who has written widely about fentanyl and the overdose crisis.